Retatrutide is an investigational peptide designed to support weight loss and metabolic health by acting as a multi-receptor agonist. It targets receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon, which are key hormones involved in regulating appetite, energy expenditure, and glucose metabolism. By activating these pathways, Retatrutide helps reduce hunger, improve blood sugar control, and increase fat oxidation, making it a promising option for individuals struggling with obesity or metabolic disorders. Its unique ability to influence multiple hormonal systems sets it apart from traditional single-pathway treatments.
In the human body, Retatrutide works by enhancing satiety signals in the brain while simultaneously improving insulin sensitivity and promoting energy utilization. Activation of GLP-1 and GIP receptors helps slow gastric emptying and reduce food intake, while glucagon receptor stimulation increases energy expenditure and fat breakdown. This combined effect leads to significant reductions in body weight and improvements in metabolic markers such as blood glucose and lipid profiles. Because of its broad mechanism, Retatrutide is being studied as a next-generation therapy for obesity and related conditions, offering a more comprehensive approach to metabolic regulation.
Reconstitution Protocol
- Diluent/Amount: 3 mL Bacteriostatic Water
Dosage Instructions
- Suggested Dosage:
- (Start) Weeks 1-4: 1mg (10units), 3x/week.
- Weeks 5- Maintenance: Titrate as needed by 0.5mg (5units per dose)
- Dosage Frequency: 3 times a week or 1 time a week if tolerated at higher doses
- Route: Subcutaneous
- Cycle Duration: As needed.
Notes
- Subcutaneous stomach injections
- Inject in AM, in fasted state.
- Titrate as needed
- Max dose is 15mg (150 units)/ week. Higher dose does not equate to better or faster results. Take smallest dose to achieve affected result.
Peptides to Stack with Retatrutide
- CJC-1295 + Ipamorelin: Enhances growth hormone and IGF-1 levels, promoting fat metabolism, lean muscle preservation, and recovery.
- AOD-9604: A fragment of human growth hormone specifically targeting fat breakdown without affecting blood sugar or muscle.
- Tesofensine: A dopamine/noradrenaline/serotonin reuptake inhibitor peptide-like compound that boosts energy, mood, and thermogenesis.
- 5-Amino-1MQ: Inhibits NNMT enzyme activity, improving cellular energy expenditure and further enhancing fat loss at the cellular level.