VIP, or Vasoactive Intestinal Peptide, is a naturally occurring peptide that functions as a neuropeptide and hormone with wide-ranging effects on the body. It is primarily known for its ability to relax smooth muscle tissue, dilate blood vessels, and stimulate the secretion of water and electrolytes in the intestines. VIP also plays a role in regulating circadian rhythms, immune responses, and neuroprotection. Because of these diverse actions, VIP has been studied for therapeutic applications in conditions such as pulmonary hypertension, inflammatory disorders, and gastrointestinal dysfunction.
A In the human body, VIP works by binding to specific G-protein-coupled receptors (VPAC1 and VPAC2) found in various tissues, including the lungs, gut, and central nervous system. This interaction activates intracellular signaling pathways that increase cyclic AMP (CAMP) levels, leading to smooth muscle relaxation and enhanced blood flow. Additionally, VIP modulates immune cell activity, reducing inflammation and promoting tissue repair. Its neuroprotective effects are linked to improved neuronal survival and reduced oxidative stress. These combined actions make VIP an important regulator of vascular tone, digestion, and immune balance.
Reconstitution Protocol
- Diluent/Amount: 3 mL Bacteriostatic Water.
Dosage Instructions
- Dosage Range: Starting dose: 100mcg (3units) increase dose as needed up to 200mcg (6units)
- Dosage Frequency: 1-2x daily. AM & PM
- Route: Subcutaneous
- Cycle Duration: 8 weeks ON, 2 weeks OFF
- Est. Bottles needed to complete Cycle: 1-2 bottles (1 bottle= 30-90days)
Notes
- Subcutaneous stomach or thigh injections
- Injected in a fasted state AM or PM
- Will cause flushing after injection
- larger doses can cause GI track issues and hypertension.